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Model of the cooperation between MutSβ and SLX4 complexes in the cleavage of replication and recombination intermediates. During S-phase and G2, MutSβ stimulates the cleavage of replication and HR intermediates by SLX1-SLX4 and/or SLX1SLX4-XPF-ERCC1 (SX) complexes. During mitosis, MutSβ stimulates the cleavage of late replication and HR intermediates by the SMX complex to allow efficient sister chromatid separation in anaphase.
