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. Author manuscript; available in PMC: 2021 Aug 8.
Published in final edited form as: Nat Struct Mol Biol. 2021 Feb 8;28(2):210–219. doi: 10.1038/s41594-020-00555-5

Extended Data Fig. 5. Cryo-EM density around newly built regions of human RPC4, RPC5 and RPC7.

Extended Data Fig. 5

a, Newly built RPC4 dimerization domain shown in molecular context (cartoon). b, RPC5 C-terminal domain, built into map F, is anchored to RPC2 and RPC4. c, Stalk bridge connecting the heterotrimer. Black mesh representation shows a 5 Å low-pass filtered cryo-EM density. Key interacting residues Y87 of RPC7 and R107 of RPC9 are shown in a close-up. The corresponding cryo-EM density is shown as blue mesh and belongs to map B2 (RELION multi-body refinement on elongating Pol III) sharpened by density modification.