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. Author manuscript; available in PMC: 2021 Apr 26.
Published in final edited form as: Nat Methods. 2017 Sep 28;14(11):1024–1025. doi: 10.1038/nmeth.4462

Figure 1. Example of an EDA diagram.

Figure 1

EDA diagram representing a two-group comparison in which each cage contains mice randomized to either of two treatments. Diagrams are composed of nodes and links to represent an entire experimental plan. The gray nodes contain high-level information about the experiment such as the null and alternative hypotheses, the effect of interest, the experimental unit and the animal characteristics. The blue and purple nodes represent the practical steps carried out in the laboratory such as the allocation to groups, the group sizes and role in the experiment, the treatments and the measurements taken. The green and red nodes represent the analysis, the outcome measures and the independent variables of interest and nuisance variables (e.g., blocking factors). For more details, see https://eda.nc3rs.org.uk.