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. Author manuscript; available in PMC: 2021 Apr 27.
Published in final edited form as: Nat Struct Mol Biol. 2020 Jul 13;27(8):743–751. doi: 10.1038/s41594-020-0457-x

Extended Data Fig. 5. Conformation al changes and putative DNA binding sites in the apo condensin complex.

Extended Data Fig. 5

a, Structural alignment of pseudo-atomic models of overall apo complexes in the non-engaged and bridged states. b, Electrostatic potential maps of Ycs4 (left) and the Smc2–Smc4 heads and coiled coils (right); red: –5 keT, blue: +5 keT. The dotted line indicates a putative path for a DNA double helix that goes through the coiled coils above the ATPase heads and also includes the positively charged patch on Ycs4 near the ‘proboscis’ protrusion. c, Placement of a DNA double helix in the space between the neck regions of the Smc2 and Smc4 coiled coils in the apo non-engaged state, based on a comparison to a DNA co-crystal structure of the E. coli SbcC (Rad50) head dimer in the engaged state (PDB code 6S85).