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. Author manuscript; available in PMC: 2021 May 13.
Published in final edited form as: J Cell Sci. 2018 Oct 4;131(19):jcs214304. doi: 10.1242/jcs.214304

Fig. 2. p62 as a cargo receptor in selective autophagy.

Fig. 2

a) Schematic overview of the domain structure of p62, which mediates its functions as indicated. Abbreviations: Phox and Bem1 domain (PB1, 21 – 103 amino acids (aa)); zinc-finger domain (ZZ, 128 - 163 aa); TRAF6 binding domain (TB, 225 - 250 aa); LC3-interacting region (LIR, 338 - 341 aa); Keap1-interacting region (KIR, 346 - 359 aa); ubiquitin-binding domain (UBA, 386 – 440 aa); nuclear localization signal (NLS1 and NLS2); nuclear export signal (NES). b) The mechanism of cargo tethering to the isolation membrane by p62. p62 filaments capture ubiquitinated substrates and link them to the Atg8 decorated isolation membrane to mediate their incorporation into autophagosomes. The NBR1 cargo receptor presumably aids p62 in this process.