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. Author manuscript; available in PMC: 2021 May 13.
Published in final edited form as: J Cell Sci. 2018 Oct 4;131(19):jcs214304. doi: 10.1242/jcs.214304

Fig. 4. p62 phase separation in selective autophagy.

Fig. 4

Degradation of p62-ubiquitin condensates that form as a result of phase separation reactions. It is currently unclear if the phase separation reaction occurs at predefined, membrane proximal sites that are later on transformed into autophagosomes (A), or if the phase separation of p62 and ubiquitinated substrates can occur anywhere in the cells followed by their recruitment to a membrane site that is permissive for autophagosome formation (B).