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. Author manuscript; available in PMC: 2021 May 13.
Published in final edited form as: Nature. 2018 Jun 13;558(7711):540–546. doi: 10.1038/s41586-018-0217-9

Fig. 3. Efficacy of BYL719 treatment in an adult patient with severe CLOVES syndrome.

Fig. 3

a, Representative pictures of patient 1 before and 360 and 540 days after onset of BYL719 treatment. b, CT scans of patient 1 before and 360 and 540 days after onset of BYL719 treatment. The magnifications are the same. c, Clinical parameters (weight, chest girth and waist circumference) of patient 1 before and after onset of BYL719 treatment. d, Serum BNP and creatinine levels before and after onset of BYL719 treatment. e, Three-dimensional MRI-based reconstructions of the intra-abdominal vessels before and after onset of BYL719 treatment. The total volume of the venous malformation was reduced by up to 72% after 540 days of treatment.