Extended Data Table 2.

Demographic data and characteristics of IBS patients participating in food-antigen injection protocol. M, male; F, female; IBS-D, IBS diarrhea-predominant; IBS-U, IBS unsubtyped; IBS-M, IBS mixed bowel patter; n.d. = non-detected.

Patient	IBS subtype	Post-infectious IBS	Gender	Age (years)	Symptom severity (VAS pain score)	Associated psychological distress	Food antigen-specific IgE				Symptom development (time food intake)	Reported relationship between food intake and symptom generation	Reported food items associated with positive mu co sal ed ema reaction
							Soy	Wheat	Gluten	Milk
IBS 1	IBS-D	No	M	27	5	Yes	n.d.	n.d.	n.d.	n.d.	5-6 h	Diarrhea, abdominal pain, bloating	-
IBS 2	IBS-U	No	F	48	4	No	n.d.	n.d.	n.d.	n.d.	30 min - 1 day	Diarrhea, abdominal pain, abdominal cramps, belching	-
IBS 3	IBS-M	No	F	25	6	Yes	n.d.	n.d.	n.d.	n.d.	1-3 h	Diarrhea, abdominal cramps, bloating	Gluten
IBS 4	IBS-D	No	F	19	6	Yes	n.d.	n.d.	n.d.	n.d.	Immediately	Diarrhea, abdominal pain, abdominal cramps	Soy, milk
IBS 5	IBS-D	No	M	41	2	No	n.d.	n.d.	n.d.	n.d.	3h	Abdominal cramps	Wheat, gluten
IBS 6	IBS-D	No	F	19	5	Yes	n.d.	n.d.	n.d.	n.d.	Immediately - 6 h	Diarrhea, abdominal pain, abdominal cramps, flatulence	Wheat, gluten, milk
IBS 7	IBS-D	No	F	20	5	Yes	n.d.	n.d.	n.d.	n.d.	30 min - 3 h	Abdominal pain, abdominal cramps, bloating	Wheat, gluten, milk
IBS 8	IBS-D	No	F	50	6	Yes	n.d.	n.d.	n.d.	n.d.	30 min - 4 h	Abdominal pain	Milk
IBS 9	IBS-D	Yes	M	33	4	Yes	n.d.	n.d.	n.d.	n.d.	3h	Diarrhea, abdominal cramps, flatulence, bloating	-
IBS 10	IBS-D	Yes	M	31	10	No	n.d.	n.d.	n.d.	n.d.	10 min	Abdominal pain, flatulence	-
IBS 11	IBS-D	No	F	28	9	Yes	n.d.	n.d.	n.d.	n.d.	30 min	Diarrhea, abdominal pain	-
IBS 12	IBS-D	No	F	34	6	Yes	n.d.	n.d.	n.d.	n.d.	30 min - 1 h	Diarrhea, abdominal cramps, bloating, flatulence	Soy, wheat, milk
Median	-	-	8F / 4M	29, IQR [21-39]	5.5, IQR [4.25-6]	-	-	-	-	-	30min - 3h	-	-