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The benzamide acetyl group is surface exposed in a crystal structure bound to the HDAC 2 catalytic active site (PDB: 4LY1). Four preliminary heterobifunctional molecules were synthesised. PROTAC 1 and 3 with a six carbon alkyl linker and either the VHL or Cereblon E3 ligand. PROTAC 2 and 4 with a twelve carbon alkyl linker and either the VHL or Cereblon E3 ligand.
