Table 2.
Conversion yields of [201Tl]Tl(I) to [201Tl]Tl(III) using oxidation methods 1–9. Values are average ± standard deviation (n = 3). Also shown are characteristics of the nine oxidation methods in terms of simple set-up, ability to remove the oxidising reagent after the reaction, and whether the oxidation process is compatible with radiolabelling biomolecules such as antibodies
| Oxidation method | Conversion yield | Simple set-up | Oxidant removed | Biomolecule compatible |
|---|---|---|---|---|
| 1: HCl (6 M), H2O2, and 95 °C | 98 ± 2% | Yes | No | No |
| 2A: HCl (2 M) and ozone | 3 ± 2% | No | Yes | No |
| 2B: HCl (6 M) and ozone | 12 ± 3% | No | Yes | No |
| 3: HCl (6 M), H2O2 and ozone | 95 ± 5% | No | No | No |
| 4: HCl (2 M), H2O2 and oxygen | 99 ± 1% | No | No | No |
| 5: HCl (2 M) and oxygen | 94 ± 6% | No | Yes | No |
| 6A: Chloramine-T (0.5 M HCl) | 99 ± 1% | Yes | No | Yes |
| 6B: Chloramine-T (0.1 M HCl) | 69 ± 3% | Yes | No | Yes |
| 7A: Iodo-bead (0.5 M HCl) | 99 ± 1% | Yes | Yes | Yes |
| 7B: Iodo-bead (0.1 M HCl) | 62 ± 8% | Yes | Yes | Yes |
| 8A: Trichloroisocyanuric acid (0.5 M HCl) | 99 ± 1% | Yes | Yes | Yes |
| 8B: Trichloroisocyanuric acid (0.1 M HCl) | 96 ± 2% | Yes | Yes | Yes |
| 9A: Iodogen (0.5 M HCl) | 99 ± 1% | Yes | Yes | Yes |
| 9B: Iodogen (0.1 M HCl) | 95 ± 3% | Yes | Yes | Yes |