Skip to main content
. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Nat Microbiol. 2020 Oct 26;5(12):1598–1607. doi: 10.1038/s41564-020-00813-8

Figure 3. Impact of disease severity on Ab responses in SARS-CoV-2 infection.

Figure 3

Comparison for individuals with 0-3 or 4/5 disease severity for a) peak ID50 of neutralization (p<0.0001), b) the time POS to reach peak ID50 (p=0.674), and c) the time POS to detect neutralizing activity (p=0.9156). ID50 measured using HIV-1 based virus particles, pseudotyped with SARS-CoV-2 S. Comparison in OD values for individuals with 0-3 or 4/5 disease severity for d) IgG (p=0.0635), e) IgM (p=0.0003) and f) IgA (p=0.0018) against S measured at peak ID50. G) Comparison of the peak ID50 value for individuals who were treated for hyperinflammation or not, and had 4/5 disease severity (p>0.999). Statistical significance was measured using a Mann-Whitney test. ns = not significant.