Figure 5. Ab responses in a healthcare worker cohort.

a) ID₅₀ values plotted against the time post onset of symptoms (POS) at which sera was collected. Each line represents one individual. ID₅₀ measured using HIV-1 based virus particles, pseudotyped with SARS-CoV-2 S. Asymptomatic individuals shown in green, symptomatic individuals shown in black and PCR+ HCW shown in red (for comparsion). The dotted line represents day 0 post onset of symptoms. b) Comparison of the peak ID₅₀ between asymptomatic individuals (n=10, includes 7 HCW and 3 hospital patients), healthcare workers (n=24 symptomatic HCW with no PCR test), and PCR+ individuals with either severity 0-3 (n=28) or 4/5 (n=32). The 2 PCR+ individuals sampled at early time points (<8 days POS) and did not seroconvert were not included in this analysis. c) ID₅₀ at peak neutralization is plotted with the donor matched ID₅₀ at the last time point sera was collected. The dotted line represents the cut-off for the SARS-CoV-2 pseudotyped virus particles neutralization assay. Asymptomatic donors are shown in green and symptomatic donors shown in black.