Schematic 1.

Schematic drawing of the morphological changes of chondrocytes in scaffolds with different pore sizes: a) Scaffolds with ~200 μm pores tend to facilitate cell-cell interaction and main spherical chondrocyte phenotype; b) Cells within larger spaces (e.g. 500 μm) flatten onto the struts of the scaffold as they would in a 2-D environment, assuming an elongated morphology, chondrocytes would potentially dedifferentiate.