Table 1. Potentiation by glutamate-induced Ca2+ flux in homomeric assemblies of different AMPAR subtypes.
AMPAR subtype | pEC50 (n) | Max. % response (n) a |
---|---|---|
hGluA1i b | 4.6, 4.7 (2) | 30 ± 2 (4) |
hGluA2i | 5.3 ± 0.1 (9) | 123 ± 7 (9) |
hGluA3i | 4.5 ± 0.1 (3) | 53 ± 3 (3) |
hGluA4i | 5.1 ± 0.1 (4) | 76 ± 1 (4) |
rGluA2i | 5.4 ± 0.1 (4) | 76 ± 8 (4) |
the maximum response is defined in terms of the positive control LY404187
MDI-222 was tested 4 times and gave a consistent max response (30 ± 2%) but in only 2/4 assays was it possible to reliably calculate pEC50 values.
Values shown are mean ± standard error of the mean