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. Author manuscript; available in PMC: 2021 Jun 2.
Published in final edited form as: J Psychopharmacol. 2019 Nov 26;34(1):93–102. doi: 10.1177/0269881119872198

Table 1. Potentiation by glutamate-induced Ca2+ flux in homomeric assemblies of different AMPAR subtypes.

AMPAR subtype pEC50 (n) Max. % response (n) a
hGluA1i b 4.6, 4.7 (2) 30 ± 2 (4)
hGluA2i 5.3 ± 0.1 (9) 123 ± 7 (9)
hGluA3i 4.5 ± 0.1 (3) 53 ± 3 (3)
hGluA4i 5.1 ± 0.1 (4) 76 ± 1 (4)
rGluA2i 5.4 ± 0.1 (4) 76 ± 8 (4)
a

the maximum response is defined in terms of the positive control LY404187

b

MDI-222 was tested 4 times and gave a consistent max response (30 ± 2%) but in only 2/4 assays was it possible to reliably calculate pEC50 values.

Values shown are mean ± standard error of the mean