. Author manuscript; available in PMC: 2021 Jun 2.

Published in final edited form as: J Psychopharmacol. 2019 Nov 26;34(1):93–102. doi: 10.1177/0269881119872198

Table 2. Effects of MDI-222 on various aspects of the AMPA-mediated inward current measured in isolated rat hippocampal neurons.

Conc. MDI-222 (no. of cells)	Responses, normalised to 30 pM AMPA alone
Conc. MDI-222 (no. of cells)	Charge transfer	Desensitisation	Deactivation
1 nM (5)	1.14 ± 0.05 ^*	0.77 ± 0.10	1.06 ± 0.04
10 nM (4)	1.37 ± 0.09 ^*	0.81 ± 0.05 ^*	1.19 ± 0.15
100 nM (4)	1.33 ± 0.12 ^*	0.76 ± 0.03 ^*	1.29 ± 0.17
1 μM (4)	1.28 ± 0.14 ^*	0.72 ± 0.04 ^*	1.33 ± 0.17
10 μM (9)	1.62 ± 0.15 ^*	0.25 ± 0.08 ^*	2.79 ± 0.43 ^*

Statistically significant changes compared to AMPA alone (* P<0.05 paired t-test). Values shown are mean ± standard error of the mean.