Figure 4. Integrative modelling of repair deficiency in HGSOC.

a) Median effect sizes of genomic features selected to predict HRD, using elastic net regularised regression on 100 training/test set splits. Model performance was measured for each split and average AUC = 0.75. Binary mutational status variables (e.g. presence/absence of BRCA1 somatic SNV) were included as factors and continuous variables were standardised to allow comparisons between variables. b) Distributions of effect size for each variable on HRD (log odds) in each training/test set split. Variables in red are selected for inclusion by the model in more than half of the training sets.