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. Author manuscript; available in PMC: 2021 Jun 14.
Published in final edited form as: Nat Struct Mol Biol. 2020 Jul 9;27(8):763–767. doi: 10.1038/s41594-020-0468-7

Figure 1. Structure of protease-cleaved SARS-CoV-2 spike glycoprotein.

Figure 1

Three structures are calculated from micrographs of furin-cleaved material: closed, intermediate and open forms of approximately equal proportions. In the uncleaved material, most of the population represents the closed form with a small proportion in the open conformation. Density maps for the three types of particles, overlaid with a ribbon representation of the built molecular models, as viewed with the long axis of the trimer vertical (middle panel); the three monomers are coloured blue, yellow and brown. An orthogonal view (lower panel) looking down the long axis (indicated by a red dot), the colouring is as in the middle panel with the NTDs in a lighter hue.