Figure 3.

Inflammation and tau PET markers are associated with clinical severity and progression. Significant regression analyses of annual change in PSPRS scores (top row) and intercept PSPRS scores (bottom row) against baseline scores for each modality-specific principal component (X axis—residual component values corrected for covariates): [¹¹C]PK11195 PET (left panel) and [¹⁸F]AV-1451 PET (right panel). Estimated parameters are reported for each model with age, education and sex as covariates. PET, positron emission tomography; PSPRS, Progressive Supranuclear Palsy Rating Scale.