Table 2. GWAS summary statistics in the UK Biobank for the 20 SNPs located in loci not previously reported or in low linkage disequilibrium (r 2<0.1) with lead SNPs previously reported.
Nearest Gene | SNP | Chr | Position (b37) | EA/OA | EA Freq | Beta | SE | P |
---|---|---|---|---|---|---|---|---|
MST01 | rs35202981 | 1 | 155578042 | G/A | 0.139 | 0.017 | 0.003 | 1.4E-08 |
EDEM3 | rs78444298 | 1 | 184672098 | G/A | 0.980 | 0.045 | 0.007 | 1.4E-09 |
GPD2 | rs111688960 | 2 | 157599687 | A/G | 0.013 | 0.051 | 0.009 | 1.2E-08 |
FAT1 | rs62342738 | 4 | 187656129 | C/G | 0.181 | 0.015 | 0.003 | 5.5E-09 |
C5orf56 | rs11242113 | 5 | 131777234 | A/G | 0.188 | 0.016 | 0.003 | 1.6E-09 |
KCNK5 | rs1544935 | 6 | 39124448 | G/T | 0.216 | 0.017 | 0.002 | 2.2E-11 |
VEGFA | rs3734692 | 6 | 43817791 | T/A | 0.310 | 0.016 | 0.002 | 1.8E-13 |
AUTS2 | rs35692677 | 7 | 69902654 | G/A | 0.813 | 0.015 | 0.003 | 1.1E-08 |
ZBTB1 | rs11990607 | 8 | 81363534 | A/G | 0.835 | 0.015 | 0.003 | 2.5E-08 |
MLLT10 | rs6482189 | 10 | 21889138 | G/A | 0.683 | 0.013 | 0.002 | 1.6E-09 |
CYP26A1 | rs2068888 | 10 | 94839642 | G/A | 0.550 | 0.012 | 0.002 | 1.0E-09 |
SBF2 | rs11042685 | 11 | 10262551 | C/T | 0.493 | 0.011 | 0.002 | 2.1E-08 |
NUMA1 | rs7115200 | 11 | 71752160 | G/T | 0.440 | 0.012 | 0.002 | 1.4E-09 |
OAF | rs12790943 | 11 | 120058623 | T/C | 0.421 | 0.011 | 0.002 | 3.0E-08 |
NAV3 | rs10860332 | 12 | 78748014 | A/G | 0.414 | 0.011 | 0.002 | 4.4E-08 |
DLEU1/BCMS | rs3116613 | 13 | 51143055 | G/T | 0.211 | 0.014 | 0.002 | 3.9E-08 |
WDR81 | rs550628400 | 17 | 1639795 | G/A | 0.006 | 0.075 | 0.013 | 2.1E-08 |
CYP2A7 | rs79600176 | 19 | 41392490 | T/C | 0.978 | 0.038 | 0.007 | 3.6E-08 |
CCDC97 | rs56254331 | 19 | 41826020 | A/C | 0.831 | 0.017 | 0.003 | 7.9E-10 |
ZBTB46 | rs11697610 | 20 | 62379531 | G/A | 0.387 | 0.012 | 0.002 | 1.9E-08 |
SNP = single nucleotide polymorphism; b37 = build 37; EA/OA = effect allele / other allele; Freq = Frequency; SE = standard error; P = P-value.