Table 3. Independent signals identified at the CUBN locus on chromosome 10.
Associations in the CUBN locus with ACR in UK Biobank whole cohort. Univariable results when each SNP is entered individually and multivariable results when all three SNPs are entered in the same regression model.
| SNP | Position (b37) | Effect/Other Allele | Frequency Effect Allele | Model | Beta | SE | P | |
|---|---|---|---|---|---|---|---|---|
| CUBN | rs141640975 | 10:16992011 | A/G | 0.003 | Univariable Multivariable |
0.463 0.470 |
0.022 0.022 |
4E-99 3E-102 |
| rs45551835 | 10:16932384 | A/G | 0.014 | Univariable Multivariable |
0.188 0.156 |
0.009 0.010 |
2E-90 1E-56 |
|
| rs45619139 | 10:16940846 | G/C | 0.101 | Univariable Multivariable |
0.059 0.040 |
0.004 0.004 |
1E-57 7E-25 |
SNP = single nucleotide polymorphism; b37 = build 37; SE = standard error; P = P-value