Skip to main content
. Author manuscript; available in PMC: 2021 Jun 17.
Published in final edited form as: Diabetes. 2020 Jan 8;69(5):1072–1082. doi: 10.2337/db19-0862

Table 4. Haplotype associations with ACR based on the 3 SNPs in the CUBN locus.

Effect sizes are given in standard deviations of inverse-normalized ACR and are relative to the baseline haplotype group formed by the three common alleles of the three SNPs. The χ2 test statistics and P-values for each haplotype correspond to the significance of the association when compared against all other haplotypes pooled. Alleles are ordered across haplotypes based on genomic position and represent 1) the low-frequency variant rs45551835, 2) the common variant rs45619139, and 3) the rare variant rs141640975.

Haplotype Frequency Additive Effect 95% CI 2 P
G-C-G (000) 0.895 REF REF 352.7 1E-78
G-G-G (010) 0.086 0.039 0.031, 0.047 72.6 2E-17
A-G-G (110) 0.013 0.201 0.181, 0.221 370.1 2E-82
G-C-A (001) 0.003 0.482 0.437, 0.527 421.9 2E-94
A-C-G (100) 0.001 0.138 0.065, 0.211 15.2 1E-04

95% CI = ninety-five percent confidence interval; χ2= chi-squared test statistic; P = P-value