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. Author manuscript; available in PMC: 2021 Jun 21.
Published in final edited form as: Neuroscience. 2016 Nov 30;343:55–65. doi: 10.1016/j.neuroscience.2016.11.031

Fig. 2. Spontaneous activity of dissociated cortical cultures at different developmental stages.

Fig. 2

(A–C) show spatial maps of action potential amplitude obtained using high-density complementary metal-oxide semiconductor microelectrode arrays (CMOS MEAs). CMOS MEAs from the same culture at 4 days in vitro (DIV) (A), 7 DIV (B), and 16 DIV (C). Black (and green) circles indicate designated recording sites. (D–F) show examples of mean spike waveforms (red lines) detected at the green circles in (A–C), respectively. The gray lines depict all traces of spike waveforms. Raster plots of 120 s of spontaneous spiking activity out of 30 min of recorded data are shown in G–I. Activities were recorded from the same dissociated cortical culture shown in (A–C) at 4 DIV (G), 7 DIV (H), and 16 DIV (I). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)