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. Author manuscript; available in PMC: 2021 Jun 22.
Published in final edited form as: Nat Cancer. 2021 Apr 26;2(6):643–657. doi: 10.1038/s43018-021-00200-0

Extended Data Fig. 7. Putative outcomes of all possible base-base mismatches.

Extended Data Fig. 7

Outcomes from 12 possible base-base mismatches. The red and black strands represent lagging and leading strands, respectively. The arrowed strand is the nascent strand. The highlighted pathways are the ones that generate C>A (blue), C>T (red) and T>C mutations (green) in the &#ΔMSH2 mutational signature.