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. Author manuscript; available in PMC: 2021 Jun 22.
Published in final edited form as: Nat Cancer. 2021 Apr 26;2(6):643–657. doi: 10.1038/s43018-021-00200-0

Extended Data Fig. 9. Gene-specific mutational signatures in MMR-deficiency.

Extended Data Fig. 9

Proportion of different mutation types of substitution (a) and indel (b) signatures for 4 MMR gene knockouts. (c) The ratio of substitution and indel burden. (d) Schematic interpretation of the relative mutation burdens of &#ΔMSH2 and &#ΔMSH6.