Extended Data Fig. 4. The liver-clock affects the composition of lung and WAT rhythmic transcriptome.
(a) The transcriptomic data of either WAT or lung was subdivided into 15 subsets, based on their rhythmicity in each of the four conditions (AlbCre AL, AlbCre DF, BLKO AL, BLKO DF). For each condition a gene is consider rhythmic if overall Qmin <0.05, and PHR<0.05 in this condition (JTK_CYCLE and Harmonic Regression, see also Methods section). Depicted is a tabular summary of all the subsets and categories (L-Bmal1= Liver-Bmal1). (b, c) Bar plot representation of the size of each subset in WAT (b) and lung (c), with coloration according to the categories as in (a). (d, e) Ingenuity Upstream Regulators analysis for each category in WAT (d) and lung (e) (presented are transcriptional regulators, P<0.001, and at least 20 targets in the category).