Table 3. Survival outcomes based on the kinetics of MRD at TP1 and TP2.
Survival | MRD | kinetics | p-value | Hazards Ratio | 95% Confidence Interval |
---|---|---|---|---|---|
OS | MRD -ve at TP1 vs | MRD -ve at TP2 | .615 | 1.3 | 0.45-3.79 |
MRD -ve at TP1 vs | MRD + ve at TP1 & TP2 | .037 | 2.2 | 1.05-4.83 | |
EFS | MRD -ve at TP1 vs | MRD -ve at TP2 | .470 | 1.4 | 0.54-3.77 |
MRD -ve at TP1 vs | MRD + ve at TP1 & TP2 | .021 | 2.2 | 1.13-4.46 | |
RFS | MRD -ve at TP1 vs | MRD -ve at TP2 | .626 | 1.4 | 0.36-5.43 |
MRD -ve at TP1 vs | MRD + ve at TP1 & TP2 | .042 | 2.6 | 1.03-6.71 |
OS: overall survival; EFS: event free survival; RFS: relapse free survival; MRD: measurable residual disease; TP1: time point 1; TP2: time point 2.