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. Author manuscript; available in PMC: 2021 Jul 10.
Published in final edited form as: Cancer Res. 2020 Apr 17;80(12):2586–2598. doi: 10.1158/0008-5472.CAN-19-2660

Figure 6. Administration of NAC rescues metastasis.

Figure 6

(A) Schematic illustration of the rescue experiment to investigate the influence of ROS on regulating tumor cell-Angpt2 mediated metastasis. (B) Control or Angpt2-deficient RET cells were injected into the tail vein of C57BL/6N mice. Mice were administered either regular water or water containing 1g/l NAC. Mice were sacrificed after 14 days. Shown are the representative images of lung metastatic foci imaged under a stereomicroscope. Scale bar: 5mm. (C) The graph represents the quantitation of lung metastatic foci (n=12; mean ± SD). *, p<0.05, **, p<0.01, Mann Whitney U test.