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. Author manuscript; available in PMC: 2021 Dec 3.
Published in final edited form as: Nat Genet. 2021 Jun 3;53(7):1104–1111. doi: 10.1038/s41588-021-00877-0

Figure 1. Schematic of QUILT model.

Figure 1

Model shown for one Gibbs sampling. Model is initialized for a vector of read labels, and a subset of reference haplotypes. The QUILT model then iteratively proceeds between Gibbs sampling, to obtain new read labels given the current subset of reference haplotypes, and full haploid imputation, to obtain new reference haplotype subsets using the current read labels. QUILT completes after a pre-specified number of iterations. Genotype dosage is taken as an average across Gibbs samplings, while phase is taken from an additional Gibbs sampling using read labels taken as average across previous samplings.