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. Author manuscript; available in PMC: 2021 Dec 3.
Published in final edited form as: Nat Genet. 2021 Jun 3;53(7):1104–1111. doi: 10.1038/s41588-021-00877-0

Figure 6. Imputation accuracy of HLA loci.

Figure 6

Accuracy is percent of correct unphased HLA alleles versus computationally inferred truth. Results are shown both per-population and in aggregate (ALL). Results are given both using only imputation (Imp only), as well as imputation plus direct read mapping (Joint, the default QUILT output). Results are further given at the subset of individuals with confidently inferred alleles (Joint(>0.90)). As reported elsewhere29, HLA Class I loci (HLA-A, HLA-B and HLA-C) are less diverse than Class II loci (HLA-DRB1 and HLA-DQB1) and thus yield more accurate imputation results.