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. Author manuscript; available in PMC: 2021 Jul 12.
Published in final edited form as: J Membr Biol. 2020 Sep 25;253(5):459–468. doi: 10.1007/s00232-020-00139-w

Fig. 3. CTR family in Mammals, Saccharomyces cerevisiae and Schizosaccharomyces pombe.

Fig. 3

Mammalian CTR1 resides on the plasma membrane in basal condition and transports copper to the copper chaperons, ATOX1, CCS, and COX1. hCTR2 localizes on endosomal membranes. In S. cerevisiae, both yCTR1 and yCTR3 serve as plasma membrane copper importers. In S. pombe, yCTR4 and yCTR5 heterotrimerizes to form a functional channel and localize at the plasma membrane. yCtr6 localizes on endosomal membrane in all copper conditions. The N-terminal regions of the CTRs of different species impart function variability (variable regions of this domain are shown in different colors)