Table 1. The members of the CTR family.

CTR	Cellular localization	Function (low/high-affin-ity cu transport)	Organism(s)	Regulation (if known)	References
1	Cell membranenucleus(yeast)	High affinity	S.cerevisiae H.sapiens Sus scrofa A.thaliana Chlamydomonas reinhardtii	Endocytosis, proteolytic cleavage	Yeast: (Dancis et al. 1994) Yeast & human: (Puig et al. 2002) Human:(Zhou and Gitschier 1997) Mouse: (Lee et al. 2000) Arabidopsis: (Kampfenkel et al. 1995) Chlamydomonas: (Page et al. 2009)
2	Vacuolar membrane late endosome recycling endosome	Low affinity (high affinity in A.thaliana)	S.cerevisiae H.sapiens A.thaliana Chlamydomonas reinhardtii	-	Yeast & Arabidopsis: (Kampfenkel et al. 1995) Yeast: (Bellemare et al. 2002) Human: (Zhou and Gitschier 1997) Arabidopsis: (Puig et al. 2007) Chlamydomonas: (Page et al. 2009)
3	ER, cell membrane	High affinity	S.cerevisiae Chlamydomonas reinhardtii A. thaliana	-	Yeast: (Peña et al. 2000), (Puig et al. 2002) Arabidopsis: (Puig et al. 2007) Chlamydomonas: (Page et al. 2009)
4	Cell membrane	High affinity	S.pombe Cryptococcus neoformans	Transcriptional, Cuf1 TF, CuRE promoter	Yeast: (Zhou and Thiele 2001) Cryptococcus: (Waterman et al 2007)
5	Cell membrane ER, fungal-type vacuole	High affinity	S.pombe A.thaliana	Transcriptional, Cuf1 TF, CuRE promoter	Yeast: (Zhou and Thiele 2001) Arabidopsis: (Puig et al. 2007)
6	Vacuolar membrane, plasma membrane	Mobilizes (low affinity) (high affinity in A.thaliana)	S.pombe, A.thaliana	Transcriptional	Yeast: (Bellemare et al. 2002) Arabidopsis: (Puig et al. 2007)