Table 2. Dose limiting toxicities (DLT) observed within the dose escalation phase by treatment cohort.

Cohort	Patient	DLT criteria met (and associated details)
1 (n=4)	61	Other clinically significant grade 3 or above toxicity except nausea or vomiting (grade 3 pulmonary embolism)
	51	Grade 4 neutropenia ≥ 7 days duration
	52	Grade 3-4 neutropenia associated with a temperature ≥38.5°C
2 (n=8)	41	Grade 3-4 neutropenia associated with a temperature ≥38.5°C
3 (n=5)	54	Grade 3-4 neutropenia associated with a temperature ≥38.5°C Grade 4 thrombocytopenia ≥ 7 days duration Greater than 14 days of delay in commencing a second cycle of treatment due to drug toxicity
	80	Grade 4 thrombocytopenia ≥ 7 days duration Grade 4 neutropenia ≥ 7 days duration Other clinically significant grade 3 or above toxicity except nausea or vomiting (grade 3 dental infection)
	63	Other clinically significant grade 3 or above toxicity except nausea or vomiting (grade 3 diarrhoea and grade 3 hypokalaemia)