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. Author manuscript; available in PMC: 2021 Oct 6.
Published in final edited form as: Sci Signal. 2021 Apr 6;14(677):eaav0320. doi: 10.1126/scisignal.aav0320

Fig. 2. Chemical space shared by the currently reported G protein–biased ligands at μ-OR and ĸ-OR.

Fig. 2

(A) Chemical structures of currently described G protein–biased ligands at the μ-OR and ĸ-OR. Of these, nalfurafine shows moderate selectivity at ĸ-OR compared with μ-OR and δ-OR, whereas the others exhibit substantial selectivity for the different receptors. (B) The different types of ligand bias that can be potentially manifested by opioid receptors.