Figure 1. Protein domains of MYC and their canonical function.

Amino acid sequence analysis identified different degrees of conservation within MYC proteins. While the C-terminal domain responsible for DNA binding is entirely conserved only small stretches – the MYC boxes – show a high degree of conservation in the remaining part of the protein. The conservation score shown in the figure was calculated as described in REF ¹²⁶. Function definitions of MYC boxes 0–IV are based on deletion and/or point mutations. Examples of proteins that interact with the relevant MYC boxes are indicated. AURKA, Aurora kinase A; BR, basic region; FBXL3, F-box and leucine rich repeat protein 3; FBXW7, F-box and WD repeat domain containing 7; GSK3,glycogen synthase kinase 3; HCFC1, host cell factor C1; MAX MYC associated factor X; MIZ1,MYC interacting zing finger protein 1; P400, E1A binding protein p400 ; PIN1, peptidylprolyl cis/trans isomerase NIMA-interaction 1; PP2A, serine/threonine protein phosphatase 2A; TFIIF, general transcription factor IIF subunit 1; TRRAP, transformation/transcription domain associated protein; WDR5, WD repeat domain 5.