Table 3. Estimates from various Mendelian randomization methods for the association between gallstone and gallbladder cancer.
| Method | OR | 95% LCI | 95% UCI | P value |
|---|---|---|---|---|
| MR estimates (SNPs=26) | ||||
| MR Egger | 1.62 | 1.00 | 2.63 | 0.062 |
| Weighted median | 1.49 | 1.15 | 1.94 | 0.003 |
| Inverse variance weighted | 1.53 | 1.16 | 2.02 | 0.003 |
| Simple mode | 1.59 | 0.96 | 2.65 | 0.084 |
| Weighted mode | 1.34 | 1.09 | 1.65 | 0.011 |
| Test for directional horizontal pleiotropy test | ||||
| Egger intercept (SE) | -0.014 (0.046) | 0.774 | ||
| MR estimates After removing outlier SNPs(n=21) | ||||
| MR Egger | 1.54 | 1.12 | 2.13 | 0.016 |
| Weighted median | 1.60 | 1.22 | 2.10 | ≤0.001 |
| Inverse variance weighted | 1.50 | 1.23 | 1.83 | ≤0.001 |
| Simple mode | 1.86 | 1.07 | 3.24 | 0.040 |
| Weighted mode | 1.62 | 1.24 | 2.11 | 0.002 |
| Test for directional horizontal pleiotropy test after removing outlier SNPs(n=21) | ||||
| Radial Egger intercept (SE) | -0.007(0.028) | 0.814 | ||
| MR-PRESSO raw estimates(SD) | 1.53(0.21) | 0.006 | ||
| MR-PRESSO outlier corrected estimate(SD) | 1.39(0.14) | 0.003 | ||
| Distortion coefficient | 0.303 | |||
| Contamination mixture method | 1.57 | 1.00 | 1.99 | 0.050 |
Abbreviations: LCI, Lower Confidence Interval; NCI, Upper Confidence Interval; OR, Odds ratio