Table 4. Multivariable-adjusted hazard ratios* (95% CI) for prostate cancer by time to diagnosis in relation to haematological indices.
| Diagnosed < 4 years from baseline | Diagnosed ≥ 4 years from baseline | |||||
|---|---|---|---|---|---|---|
| Cases | HR (95% CI) | Cases | HR (95% CI) | Phet | ||
| Red blood cell | ||||||
| Red blood cell count (1012 cells/L) | 2938 | 1.04(1.01-1.08) | 2785 | 1.10(1.06-1.14) | 0.07 | |
| Red blood cell distribution width (%) | 2938 | 1.02(0.98-1.06) | 2785 | 1.03(0.99-1.07) | 0.77 | |
| Haematocrit (%) | 2938 | 1.01(0.98-1.05) | 2785 | 1.03(0.99-1.07) | 0.52 | |
| Haemoglobin concentration (g/dL) | 2938 | 1.01(0.97-1.04) | 2785 | 1.01(0.97-1.05) | 0.98 | |
| Mean corpuscular volume (pg) | 2938 | 0.95(0.91-0.99) | 2785 | 0.90(0.86-0.93) | 0.04 | |
| Mean corpuscular haemoglobin (g/dL) | 2938 | 0.95(0.91-0.99) | 2785 | 0.88(0.85-0.92) | 0.01 | |
| Mean corpuscular haemoglobin conc (g/dL) | 2938 | 0.99(0.95-1.02) | 2785 | 0.94(0.91-0.98) | 0.13 | |
| Mean sphered cell volume (fL) | 2886 | 0.97(0.93-1.01) | 2746 | 0.90(0.86-0.94) | 0.01 | |
| Reticulocyte count (1012 cells/L) | 2885 | 0.98(0.94-1.03) | 2746 | 1.00(0.96-1.04) | 0.57 | |
| Platelet | ||||||
| Platelet count (109 cells/L) | 2938 | 1.03(0.99-1.06) | 2785 | 1.09(1.05-1.13) | 0.02 | |
| Platelet distribution width (%) | 2938 | 0.99(0.96-1.03) | 2785 | 0.99(0.96-1.03) | 0.96 | |
| Mean platelet volume (fL) | 2885 | 0.99(0.96-1.03) | 2729 | 1.02(0.98-1.05) | 0.42 | |
| White blood cell | ||||||
| White blood cell count (109 cells/L) | 2932 | 0.99(0.95-1.03) | 2778 | 1.04(1.00-1.08) | 0.12 | |
| Neutrophil count (109 cells/L) | 2931 | 1.01(0.97-1.05) | 2780 | 1.05(1.01-1.09) | 0.17 | |
| Eosinophils (109 cells/L) | 2930 | 0.97(0.93-1.01) | 2777 | 0.98(0.94-1.02) | 0.87 | |
| Basophil count (109 cells/L) | 2920 | 1.00(0.96-1.04) | 2766 | 0.98(0.94-1.03) | 0.51 | |
| Monocyte count (109 cells/L) | 2931 | 1.00(0.96-1.04) | 2780 | 1.00(0.96-1.05) | 0.88 | |
| Lymphocyte count (109 cells/L) | 2931 | 0.97(0.93-1.02) | 2780 | 1.00(0.96-1.04) | 0.34 | |
HRs per 1 SD increase are stratified by region and age at recruitment and adjusted for age (underlying time variable), Townsend deprivation score, racial/ethnic group, height, lives with a wife or partner, BMI, cigarette smoking, alcohol consumption and diabetes.
Phet was estimated using stratified Cox models based on competing risks (<4 and ≥4 years from recruitment to diagnosis), and tested using the χ2 test of heterogeneity).
Abbreviations: BMI=body mass index; CI=confidence intervals; HR=hazard ratio; SD=standard deviation.≥