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. Author manuscript; available in PMC: 2021 Jul 25.
Published in final edited form as: Nat Genet. 2021 Jan 25;53(2):128–134. doi: 10.1038/s41588-020-00762-2

Extended Data Fig. 7. Manhattan and QQ plots of LV global circumferential strain GWAS and MTAG.

Extended Data Fig. 7

a,b, Summary results of the left ventricular global circumferential strain (straincirc) GWAS in the UK Biobank (N=19,260) shown as Manhattan plots for the single trait (a) and the multi-trait analyses (MTAG; b). Single trait analysis (a) consisted of a fixed effects meta-analysis of case-control GWAS using a linear mixed model (BOLT-LMM), and multi-trait analysis results (b) were obtained using MTAG including summary statistics for all nine left ventricular (LV) traits. Red dashed line shows the significance threshold of P = 1 × 10-8. Quantile-quantile (QQ) plots shown as inserts in corresponding panels. Genomic inflation (λ) = 1.046 (single-trait) and 1.061 (MTAG). Numbering of signals as shown in Supplementary Table 8.