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. Author manuscript; available in PMC: 2021 Jul 25.
Published in final edited form as: Nat Genet. 2021 Jan 25;53(2):128–134. doi: 10.1038/s41588-020-00762-2

Extended Data Fig. 1. Manhattan and QQ plots of DCM GWAS and MTAG.

Extended Data Fig. 1

a,b, Summary results of the dilated cardiomyopathy (DCM) GWAS meta-analysis of 5,521 cases and 397,323 controls shown as Manhattan plots for the single trait (a) and the multi-trait analyses (MTAG; b). Single trait analysis (a) consisted of a fixed effects meta-analysis of case-control GWAS using summary statistics of three previously published DCM GWAS, and multi-trait analysis results (b) were obtained using MTAG for DCM, including GWAS for hypertrophic cardiomyopathy (HCM) and nine left ventricular (LV) traits. Red dashed line shows the significance threshold of P = 1 × 10-8. Quantile-quantile (QQ) plots shown as inserts in corresponding panels. Genomic inflation (λ) = 1.028 (single-trait) and 1.049 (MTAG). Numbering of signals as shown in Supplementary Table 7. Black numbers refer to loci reaching the statistical significance threshold in single trait analysis, while red numbers refer to loci only reaching statistical significance in the multi-trait analysis. The low density of association signals in the single trait analysis (a) is attributable to the inclusion of a large sample size study that used a low density array (Illumina Infinium HumanExome BeadChip; Supplementary Table 5).