Table 2.

Comparison of maternal and pregnancy characteristics and outcomes in MGP between women with confirmed COVID‐19 and a pre‐pandemic cohort ^a

Characteristics	Pre‐pandemic period	Pandemic period	P value
Total deliveries	3289	603
Total cesarean deliveries	1402 (43)	233 (38.6)
Prenatal admission	6401	852 b
Twinning rate per 1000 births	37.6	34.2
MGP cohort	63	10 c
Maternal age, years	27 (25–31.5)	31.5 (29.5–34.5)	0.009
Primigravida	14 (22.2)	5 (50.0)	0.114
IVF conception	Data not available	7 (70.0)	NA
Gestational hypertension	2 (3.2)	0	NA
Pre‐eclampsia	7 (11.1)	4 (40.0)	0.091
Eclampsia	1 (1.6)	1 (10.0)	0.257
Gestational diabetes mellitus	1 (1.6)	0 (0)	NA
High‐risk pregnancy	3 (4.6)	0 (0)	NA
Heart disease	1 (1.6)	0 (0)
Hepatitis E	1 (1.6)	0 (0)
Blood transfusion	8 (12.7)	2 (20.0)	0.619
Preterm birth	46 (73.0)	6 (60.0)	0.459
PPROM/PROM	6 (9.5)	3 (30.0)	0.101
Delivery
Vaginal	28 (44.4)	4 (40.0) d
Cesarean	35 (55.6)	7 (70.0) d	0.723
Delivery outcome
Live birth e	117 (92.8)	21 (100)
Stillbirth e	9 (7.2)	0 (0)	0.358
Postpartum complications
Postpartum hemorrhage	2 (3.2)	1 (10.0)	0.362
PRES	1 (1.6)	0 (0)	NA
NICU admission f	79 (67.5)	8 (38.1)	0.014
Neonatal death	1 (1.6)	0 (0)	NA

Abbreviations: IVF, in vitro fertilization; MGP, multiple gestation pregnancy; NA, not applicable; NICU, neonate intensive care unit; PPROM, preterm PROM; PRES, posterior reversible encephalopathy syndrome; PROM, premature rupture of membrane.

^a The pandemic period was April 4 to September 10, 2020; the pre‐pandemic period was April 1, 2019, to March 31, 2020. Values are given as median (interquartile range) or number (percentage).

^b Includes 27 postnatal admissions.

^c Two postnatal admissions were not included in the analysis.

^d First twin delivered vaginally and second delivered by cesarean.

^e Sample size: n = 126 for pre‐pandemic period and n = 21 for pandemic period.

^f Among total live births. Sample size: n = 117 for pre‐pandemic period and n = 21 for pandemic period.