| ErbB1/2 inhibition (Lapatinib) ERBB2 RNAi CTSB/CTSL RNAi |
Perinuclear |
ND |
Attenuated invasion |
[21,22] |
| Cationic amphiphilic drugs Siramesine |
Perinuclear |
ND + |
Expansion of lysosomal compartment |
[67]; Unpublished observations |
|
BORCS5 (BORC complex protein) KO, ARL8B RNAi |
Perinuclear |
ND |
Reduced cell adhesion and motility, Lysosome traffic |
[17,27] |
|
KIF2A, KIF1B RNAi, Starvation |
Perinuclear |
ND |
mTORC activation, autophagy modulation |
[10] |
|
KIF20A, KIF25 RNAi, KIF5B RNAi |
Peripheral/protrusions |
+ |
Accumulation of autophagosomes |
[57,68] |
|
DHC, Htt RNAi, RUFY1, δ-adaptin RNAi |
Peripheral/protrusions |
ND |
Exaggerated protrusions, Lysosomal detachment from MTs |
[32,33] |
|
RAB7 shRNA |
ND |
ND |
Hydrolase secretion, increased invasion |
[69] |
|
TPM2, MYH1 RNAi |
Peripheral/protrusions |
+ |
Cell death |
[57] |
|
TMEM106b shRNA
|
Peripheral |
+ |
Increased lysosomal axonal motility |
[16] |
| Cambinol (HDAC inhibitor), Troglizatone (PPARγ agonist), EIPA, (sodium-proton exchanger inhibitor) |
Perinuclear |
ND |
Attenuated invasion |
[28,31], Dykes et al, 2015 |
