Table 1. Yeast gene candidates selected for screening.
Group 1 | Genes with diminished response to exogenous CoQ2 and CoQ4 [39] | ZDS1, RTS1, IKI3, ELP4, QCR9, ACO1, MDL2, SAC1, SWF1, ARV1, CDC10, KCS1, EMI1, MET18, RPL31A, HTA1, CSR1, HES1 |
Group 2 | Yeast major clathrin-mediated endocytic factors [53] | SYP1, EDE1, CHC1, CLC1, SLA2, END3, SLA1, VRP1, BZZ1, MYO3, MYO5, BBC1, RVS161, RVS167, ABP1 |
Group 3 | ER-mitochondria encounter structure (ERMES) | MMM1, MDM10, MDM12, MDM34 |
Group 4 | Nucleous-vacuole junction (NVJ) | VAC8, NVJ1 |
Group 5 | Vacuole-mitochondria patch (vCLAMP) | YPT7, VAM6, VAM7 |
Group 6 | Genes previously described to be required for CoQ6 rescue [33] | TLG2, PEP12, ERG2, VPS45 |
Group 7 | Nat B complex | MDM20, NAT3 |
Genes depicted in light grey represent the ORFΔcoq2Δ double mutants that were not recoverable for the ORFΔcoq2Δ library.