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. Author manuscript; available in PMC: 2021 Jul 22.
Published in final edited form as: Bioconjug Chem. 2020 Nov 26;32(7):1242–1254. doi: 10.1021/acs.bioconjchem.0c00561

Figure 10. In vivo biodistribution and tumor targeting of [99mTc][Tc(CO)3]+-J591scFvJWT and [99mTc][Tc(CO)3]+-J591scFv’ showing specific uptake in PSMA-expressing tumor.

Figure 10

A. Example SPECT-CT images (75–90 min post-injection). B. Ex vivo biodistribution (90 min post-injection) of mice bearing DU145 tumor (non-PSMA expressing, indicated by yellow arrows, right images) and DU145-PSMA tumor (PSMA expressing, indicated by yellow arrows, left images) after administration of [99mTc][Tc(CO)3]+-J591scFvJWT (top images) or [99mTc][Tc(CO)3]+-J591scFv (bottom images). si = small intestine; li = large intestine; rep = reproductive; sal = salivary. Error bars represent standard deviation, n = 4 per group.