Table 2.

Family	Subunit		Syndrome/NDD	Mutations	Clinical brain Phenotypes	References
	Gene	Protein
NuRD	CHD3	CHD3	Snyders Blok-Campeau Syndrome	Missense, nonsense, frameshift, deletion, splice-site variant	ID, DD, delayed myelination, macrocephaly/microcephaly	Drivas et al. (2020); Snijders Blok et al., 2018
	CHD4	CHD4	Sifrim-Hitz-Weiss syndrome (SIHIWES)	Missense, in-frame deletions, nonsense	ID, DD, macrocephaly, hydrocephalus, thin corpus callosum,	Farnung et al. (2020); Weiss et al. (2020)
	CHD5	CHD5	Autism-like	Missense	DD, cerebral palsy, speech impairment	http://www.mygene2.org [03 October 2020 accessed]
	MBD2/3	MBD2/3	Autism	SNPs		Cukier et al. (2009); Li et al. (2005)
	HDAC1/2	HDAC1/2	Schizophrenia, Angelman syndrome	–	ID, DD	Jamal et al. (2017); Schroeder et al. (2017); Sharma et al. (2008)
	GATAD2B	GATAD2B	GATAD2B-associated neurodevelopmental disorder (GAND)	Deletion, frameshift, nonsense, splice-site, missense	ID, DD, macrocephaly, thin corpus callosum, widened CSF spaces, hypomyelination	de Ligt et al. (2012); Hamdan et al. (2014); Luo et al, 2017; Shieh et al. (2020); Ueda et al. (2019); Willemsen et al. (2013)
	KDM1A	KDM1A	Kabuki and KBG-like syndrome	Missense, nonsense, splice-variant, nonsense	ID, DD, thin corpus callosum, delayed myelination, cerebellar defects	Chong et al., 2015; Rauch et al. (2012); Tunovic et al. (2014)
BAF	ARIDla	BAF250A	Coffin Siris Syndrome	Nonsense, frameshift indel, missense	CNS structural abnormalities	Bramswig et al. (2017); Tsurusaki et al. (2012); Wieczorek et al. (2013)
	SMARCA4	BRG1
	SMARCE1	BAF57
	ARID2	BAF200
	SMARCA2	BRM	Coffin Siris syndrome, Nicolaides-Baraitser syndrome, Schizophrenia	Partial deletion, missense, intronic alteration, duplication	CNS structural abnormalities, ID, microcephaly, behavioural problems and seizures, delusions, thought disorder, cognitive dysfunction	Ejaz et al. (2016); Miyake et al., 2014; Sousa et al. (2014); Wolff et al., 2012
	SMARCB1	BAF47	Coffin Siris Syndrome, Kleefstra syndrome	In-frame deletion, missense	CNS structural abnormalities, ID, behavioural anomalies	Kleefstra et al., 2012; Santen et al., 2013; Tsurusaki et al. (2012); Wieczorek et al., 2013
	ARIDlb	BAF250B	Coffin Siris Syndrome, ID, Hirschsprung’s disease, Schizophrenia, Autism, 6q25 Microdeletion Syndrome	Missense, nonsense, frameshift indel, translocation, microdeletion, interstitial deletion	CNS structural abnormalities, developmental delay, epilepsy, and hypoplasia of the corpus callosum and cerebellum, delusions, thought disorder, cognitive dysfunction, defects in social and communication skills, restricted and repetitive behaviour, corpus callosum agenesis	Backx et al. (2011); Halgren et al. (2012); Santen et al., 2013; Takenouchi et al. (2016), Ronzoni et al. (2016)
	SMARCD1	BAF60	Coffin Siris Syndrome, Nicolaides-Baraitser syndrome	Missense, nonsense	CNS structural abnormalities, ID, microcephaly, behavioural problems and seizures	Machol et al. (2019); Nixon et al., 2019
	SMARCC1	BAF155	Autism	Missense	Defects in social and communication skills, restricted and repetitive behaviour	Neale et al. (2013); O’Roak et al. (2012)
	PBRM	BAF180a	Autism	Missense
	ACTL6b	BAF53b	Autism	Missense	Defects in social and communication skills, restricted and repetitive behaviour	Bell et al. (2019); Wenderski et al. (2020)
	ACTL6b	BAF53b	DECAM syndrome	–	Developmental delay, Epileptic encephalopathy, Cerebral atrophy and abnormal Myelination	Bell et al. (2019); Yuksel et al. (2019)
	BCL11a	BAF100a	Autism, Schizophrenia, p15–16.1 Microdeletion syndrome, Intellectual Disability	Microdeletion, missense, frameshift	Defects in social and communication skills, restricted and repetitive behaviour, delusions, thought disorder, cognitive dysfunction, developmental delay, hearing and visual impairment and corpus callosum agenesis	Basak et al. (2015); Bagheri et al. (2016); Chen et al. (2020); De Rubeis et al. (2014), Korenke et al. (2020)
	SMARCC2	BAF170	Coffin Siris Syndrome, Nicolaides-Baraitser syndrome like, Autism	Splice site mutation	CNS structural abnormalities, ID, microcephaly, behavioural problems and seizures, defects in social and communication skills, restricted and repetitive behaviour	Machol et al. (2019)
ISWI	SMARCA1	SNF2L	Coffin-Siris like syndrome; Schizophrenia	Nonsense, missense	ID, microcephaly with cortical atrophy, spasticity, dysmorphic features	Homann et al. (2016); Karaca et al. (2015)
	BAZ1A	ACF-1	Intellectual Disability	Missense	ID, corpus callosum agenesis	Zaghlool et al. (2016)
	BAZ1B	WSTF	Williams Syndrome	Microdeletion	Anxiety, ADHD	Lalli et al. (2016)
	BPTF	BPTF	Unnamed syndrome; Silver-Russell syndrome	Nonsense, missense, frameshift, CNV deletion, splice-variant	ID, DD, microcephaly, dysmorphic facial features; pre- and postnatal growth retardation	Stankiewicz et al. (2017); Wakeling et al. (2017)
	RAD21	RAD21	Cornelia de Lange (CdL)	LOF	Microcephaly, holoprosencephaly	Goel 2020; Kruszka et al. (2019)
	SMC1	SMC1	Cornelia de Lange syndrome and holoprosencephaly	Nonsense, missense	Holoprosencephaly	Kruszka et al. (2019)
	SMC3	SMC3	ID and holoprosencephaly	Missense, nonsense, in-frame deletion/duplication	Holoprosencephaly	Kruszka et al. (2019)
	STAG2	SA2	STAG2-related X-linked Intellectual Deficiency and holoprosencephaly	LOF	Moderate ID, language and hearing defects, developmental delay, microcephaly, characteristic facial features, holoprosencephaly	Kruszka et al. (2019); Soardi et al. (2017)
INO80/SWR1	INO80		Intellectual Disability and Global developmental delay	–	ID, DD, microcephaly	Alazami et al. (2015)
	SRCAP		Floating Harbor Syndrome	Nonsense	ID, ADHD, speech delay, cranio-facial features	Greenberg et al. (2019); Homma et al. (2019); Zhang et al. (2019)
	TIP60/KAT5		Unnamed syndrome	Missense	ID, DD, corpus callosum agenesis/dysgenesis, characteristic facial features	Humbert et al. (2020)
Other CHDs	CHD1	CHD1	Pilarowski-Bj ornsson Syndrome, 5q15-q21.2 deletion, ASD	Missense, deletion	Speech apraxia, DD, autism, craniofacial dysmorphism, motor delay	Neale et al. (2013); Pilarowski et al. (2018); Zepeda-Mendoza et al., 2019
	CHD2	CHD2	Developmental Epileptic Encephalopathy, Epilepsy with myoclonicatonic epilepsy, ASD	Nonsense, missense, deletion	Photosensitivity, myoclonic seizures, ID	Angione et al. (2019); Carvill et al. (2013); Neale et al. (2013); Trivisano et al. (2015)
	CHD7	CHD7	CHARGE Syndrome, ASD	Missense, nonsense, frameshift, microdeletions, translocation, intronic SNV	Developmental delay, hearing impairment, defects in social and communication skills, restricted and repetitive behaviour	Johnson et al. (2006); O’Roak et al., 2012; Vissers et al. (2004); Zhang et al. (2020)
	CHD8	CHD8	14q11.2 microdeletion, Zahir Friedman syndrome, Schizophrenia	de novo deletion, Microdeletion, CNVs, missense, frameshift, nonsense, single amino acid deletions, duplications, point mutations	Developmental delay, cognitive impairment, dysmorphic features, ASD/DD/ID, macrocephaly, speech defects, defects in social and communication skills, restricted and repetitive behaviour, hallucinations, persecutory delutions and catatonic behaviors	Bernier et al. (2014); Kimura et al., (2016); McCarthy et al., (2014); Merner et al., 2016; Stessman et al. (2017); Talkowski et al., 2012; Yasin et al. (2019); Yasin et al., 2020; Zahir et al., 2007