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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Cancer Discov. 2021 Apr 1;11(4):916–932. doi: 10.1158/2159-8290.CD-20-1559

Figure 2. Tumour evolution in non-small cell lung cancer.

Figure 2

Evolutionary processes in non-small cell lung cancer are outlined. Top, subclonal dynamics over time can be represented by a fish plot, however a single sample in time only provides a snapshot. From this snapshot tumour phylogeny can be inferred. Bottom, evolutionary processes generating immune and genomic heterogeneity are described as part of a ‘tree’. Events that occur in the ‘trunk’ are clonal; i.e. they occur within every cell in the tumour. Through tumour evolution, subclones can emerge through selection; events that occur in these subclones are known as ‘branch’ events.