. Author manuscript; available in PMC: 2021 Jul 24.

Published in final edited form as: Mult Scler. 2019 May 10;26(7):774–785. doi: 10.1177/1352458519845105

Table 3. Association between connectivity metrics and cognitive measures, adjusted for age, gender and T2 lesion load.

	Multi-tissue DW protocol RC (95% CI), p value (sRC)		Single-tissue DW sub-protocol RC (95% CI), p value (sRC)
	PASAT^a	SDMT^a	PASAT^a	SDMT^a
Mean nodal strength in streamlines	2.518 (−3.099 to 8.135), p = 0.353 (sRC = 0.243)	1.969 (−3.014 to 6.952), p = 0.411 (sRC = 0.215)	2.757 (−2.717 to 8.230), p = 0.298 (sRC = 0.278)	−1.120 (−6.097 to 3.856), p = 0.637 (sRC = -0.128)
Mean clustering coefficient^b	3.519 (−1.990 to 9.027), p = 0.192 (sRC = 0.350)	1.466 (−3.632 to 6.565), p = 0.547 (sRC = 0.165)	2.082 (−3.290 to 7.455), p = 0.420 (sRC = 0.209)	1.145 (−3.658 to 5.948), p = 0.617 (sRC = 0.130)
Mean shortest path^b	−0.090 (−43.912 to 43.733), p = 0.997 (sRC = -0.001)	−24.788 (−51.245 to 1.669), p = 0.064 (sRC = -0.502)	−0.147 (−7.144 to 6.850), p = 0.964 (sRC = -0.019)	−3.024 (−8.391 to 2.342), p = 0.245 (sRC = -0.463)
Global efficiency^b	2.869 (−2.637 to 8.375), p = 0.283 (sRC = 0.276)	1.041 (−3.985 to 6.067), p = 0.664 (sRC = 0.113)	1.536 (−3.561 to 6.633), p = 0.528 (sRC = 0.162)	0.836 (−3.695 to 5.367), p = 0.698 (sRC = 0.099)
Mean local efficiency^b	3.604 (−1.941 to 9.148), p = 0.185 (sRC = 0.352)	1.286 (−3.873 to 6.446), p = 0.601 (sRC = 0.142)	2.055 (−3.262 to 7.372), p = 0.421 (sRC = 0.207)	0.951 (−3.815 to 5.717), p = 0.675 (sRC = 0.108)
Modularity coefficient^b	2.729 (−3.376 to 8.833), p = 0.354 (sRC = 0.238)	−6.823 (−10.762 to −2.884), p = 0.002 (sRC = -0.673)	−0.772 (−5.688 to 4.145), p = 0.741 (sRC = -0.084)	−4.631 (−8.075 to −1.188), p = 0.012 (sRC = -0.570)

DW: diffusion-weighted; 95% CI: 95% confidence interval; RC: regression coefficient, expressed in ‘number of correct answers/network unit’; sRC: standardised regression coefficient, expressed in dimensionless units; PASAT: paced auditory serial addition test; SDMT: symbol digit modalities test. The figures within each cell represent, in order, regression coefficient, 95% CI, p value and sRC. Significant results are marked in bold.

Number of correct answers.

Dimensionless units.