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. Author manuscript; available in PMC: 2021 Jul 24.
Published in final edited form as: Lancet Haematol. 2020 Nov;7(11):e789–e797. doi: 10.1016/S2352-3026(20)30288-X

Figure 3. Odds Ratio for Death Comparing Transfused versus Not Transfused Patients across a Continuous Hemoglobin Concentration with Adjustment for Site and Disease Severity.

Figure 3.

Generalized Additive Models of the odds ratio for death were adjusted for study site, hypoglycemia, respiratory distress, impaired consciousness, parasite density, age and temperature. Data are shown for all severe malaria patients (A), and then stratified by normal consciousness (B), impaired consciousness (C), and lactate levels (D-F). In each stratification the stratum variable is not used for adjusting. The upper and lower 95% confidence intervals of the odds ratio for death are indicated by dotted lines. The 95% confidence interval of the hemoglobin concentration at which the odds ratio equals 1 was determined by a bootstrap procedure. All Severe Malaria: 77 (65,110) g/L; Normal Consciousness: 58 (52, 66) g/L; Impaired Consciousness: 105 (71,115) g/L; Lactate 2·9 mmol/L or less: 42 (28, 54) g/L; Lactate 3·0–4·9 mmol/L: 66 (52, 79) g/L; and Lactate 5·0 mmol/L or more: odds ratio model remained less than 1, upper 95% CI crosses 1 at a hemoglobin of 90 g/L.