Skip to main content
. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Nat Struct Mol Biol. 2021 Jun 10;28(6):512–520. doi: 10.1038/s41594-021-00605-6

Fig. 3. Acyl chain and CoA binding sites.

Fig. 3

a, Overview of the central acyl-CoA binding tunnel. b-d, Acyl chain binding pocket. e, Conservation of active site tunnel. Molecular surface representation is coloured by amino acid conservation score calculated by CONSURF49 analysis of a diverse set of ELOV1-7 family members. The various subregions of the tunnel are indicated (ADP / Pan from CoA and Acyl chain). Amino acid residues that form the binding tunnel are coloured according to region (pink, acyl; blue, catalytic site; orange CoA binding). f, Cytoplasmic-facing CoA 3’-phospho ADP/pantothenic (Pan) binding pocket.