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Visualization of the docking results: Protein - ligand interaction of crizotinib and prodrug A in complex with c-MET (A) and ALK (B). In both structures, the main hydrogen bonds of the 2-aminopyridine moiety of crizotinib that are essential for the tyrosine kinase inhibition are suppressed. In case of c-MET, additionally the crucial π-π interaction between the 2,6-dichloro-3-fluorophenyl moiety and Tyr-1230 is disturbed.
