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Cytotoxic activity of prodrug A, prodrug B and crizotinib against the indicated human cancer cells. Incubation time of the compounds on the cells was 24 h or 72 h under normoxic (21% O2) or hypoxic condition (1% O2). Dose-response curves (24 h and 72 h) of prodrug A (A), prodrug B (B), crizotinib (C) and TH-302 (D) in H2228, H1993 and RUMH cells are shown. Values are given as means ± SD of one representative experiment performed in triplicates. N= normoxia, H=hypoxia
