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Impact of drug treatment on the c-MET and p-ERK 1/2 phosphorylation under hypoxic (1 % O2) and normoxic (21 % O2) conditions. H1993 cells treated with crizotinib (A) or prodrug A (B). After 24 h cell lysates were prepared and protein expression and phosphorylation levels of p-c-MET and p-ERK 1/2 analyzed by Western blotting. The ratio p-c-MET to c-MET and p-ERK 1/2 to ERK 1/2 (after normalization to the loading control ß-actin) is given below the respective bands.
